Histamine Pro

Histamine Pro

Histamine Pro

Histamine Pro is a powerful blend of ingredients that can help you tackle high histamine levels, and/or oversensitivity to histamine’s effects.

  • Regulates histamine metabolism
  • Helps balance an overactive immune system
  • Useful during and beyond allergy season
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  • Can help reduce pollen and other environmental allergy symptoms
  • Reduces inflammation

  • May help to stabilize mast cells 

  • May assist with wider histamine intolerance symptoms, such as brain fog, irritability, and joint pain

Suggested Use

  • Take 2 capsules twice a day, or 1 capsule 4 times a day

  • Best taken with food or a drink

Product Facts

  • Contains Tinofend®, a patented extract of Tinospora cordifolia shown to modulate the balance of white blood cells in favor of less inflammation
  • Also provides the natural antihistamines quercetin and nettle leaf extract

  • Plus 500 mg vitamin C to support the immune system 

  • Bicarbonate salts are included for their role in also maintaining normal histamine metabolism

  • Free from gluten, dairy and soy

  • Vegetarian, vegan, and non-GMO

Why Dr. Ruscio, DC Recommends it

  • The synergistic blend of ingredients in Histamine Pro helps balance the immune response when the immune system is challenged.
  • Tinofend® is a superior form of Tinospora cordifolia extract with a guaranteed level of active ingredients (polysaccharides) to support immune health and histamine levels.

  • Supplies 600 mg quercetin (some products have less than effective amounts).

  • I recommend using Histamine Pro alongside a gut-healing diet and probiotics, as leaky gut and gut bacterial imbalance can underlie histamine intolerance.

What the Research Shows

  • In a randomized controlled trial in subjects with hay fever, Tinofend® stimulated the activity of white blood cells that regulate immune response and reduced the number of eosinophils (immune cells which release histamine). 83% patients obtained complete relief from sneezing, 69% from nasal discharge, and 61% from blocked nose [1].
  • In cell studies, quercetin stabilizes mast cells that release histamine (the principal cause of reactions to pollen and other allergies) [2] . 

  • Quercetin plant extracts may be better at inhibiting the proinflammatory cytokine IL-8 (stimulated by histamine)  than the anti-allergic drug disodium cromoglycate [2].

  • Vitamin C has also been shown to reduce serum histamine levels [3]  

  • In an animal study, nettle extract reduced allergic inflammation in the lungs of animals who were exposed to an asthma-causing allergen [4]. 

  • Histamine intolerance and IBS symptoms / causes overlap, indicating that bacterial overgrowth may be a cause for both conditions [5678]. 

  • Research suggests that probiotics lower histamine levels in the digestive tract, so Histamine Pro is always best taken with a probiotic [9].

How to Use it

For histamine intolerance

Useful if you react to histamine-rich foods or have trouble breaking down histamine.

To balance the immune system

May Modulate white blood cell balance and mast cell activation so your body becomes a less inflammatory environment.

For seasonal allergies

Can help if you have hayfever / pollen allergy symptoms, or other allergic reactions.

Frequently Asked Questions

Would it be useful to take Histamine Pro before the hayfever season starts?

If you know you are allergic to specific seasonal pollens, it would likely be helpful to start taking Histamine Pro for 4–6 weeks in advance of the season. But quicker results may also be experienced.

Can it be used for intolerance to histamines in food?

Yes, the supplement can be very helpful if you react to histamine in foods. A reduced histamine diet and a gut healing regime is the first priority, given that histamine issues normally start because of problems in the digestive tract.

Can Histamine Pro help with brain fog?

Yes, if the brain fog is related to histamine intolerance. Other common symptoms of histamine intolerance include  migraines, nasal congestion, nausea, fatigue and hives.

What other steps should I take to lower histamine?

Dr Ruscio suggests a low histamine diet and use of triple therapy probiotics. High histamine foods include fermented or aged foods like mature cheese and wine. Certain vegetables, including spinach and eggplant, also have high histamine levels.